• Analysis of methylation data with imputation with blocks (MethylBlocks) 

      Meng, Wei; Ray, Mithlesh Kumar; Fenton, Christopher Graham; Anderssen, Endre; Paulssen, Ruth H (Conference object; Konferansebidrag, 2022)
      <p><i>Background -</i> Analysis of methylation data is dependent on two inputs. The total number of reads at any given cytosine site (coverage), and how many of those cytosines are methylated (methylation). Both the large number of sites and low coverage can cause problems in the analysis of methylation data. Likewise finding DMR is computationally and statistically challenging. Here we present a ...
    • Methylation-regulated long non-coding RNA expression in ulcerative colitis 

      Fenton, Christopher Graham; Ray, Mithlesh Kumar; Meng, Wei; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22)
      Long non-coding RNAs (lncRNAs) have been shown to play a role in the pathogenesis of ulcerative colitis (UC). Although epigenetic processes such as DNA methylation and lncRNA expression are well studied in UC, the importance of the interplay between the two processes has not yet been fully explored. It is, therefore, believed that interactions between environmental factors and epigenetics ...
    • Novel long non-coding RNAs of relevance for ulcerative colitis pathogenesis 

      Ray, Mithlesh Kumar; Fenton, Christopher Graham; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-06)
      Background and aims: The study aimed to identify yet unknown and uncharacterized long non-coding RNAs (lncRNAs) in treatment-naïve ulcerative colitis (UC), and to define their possible roles in UC pathogenesis. For that purpose, accurate quantification methods for lncRNA transcript detection, multiple and “stringent” strategies were applied. New insights in the regulation of functional genes and ...
    • Novel long-coding RNAs of relevance for ulcerative colitis pathogenesis 

      Ray, Mithlesh Kumar; Fenton, Christopher Graham; Paulssen, Ruth H (Conference object; Konferansebidrag, 2022)
      <p>Introduction - LncRNAs have become a growing field of research. They are involved in diverse biological processes including expression regulation, and chromatin modification. Many lncRNAs have been characterized as involved in the occurrence and development of various human diseases, including cancer. A growing body of evidence implies a role for lncRNAs in UC by modulating the intestinal barrier, ...